- Hampstead Heath Walk 2014
- Study identifies first genetic variant which increases the risk of invasive lobular carcinoma
Hampstead Heath Walk
The first Cancerkin Hampstead Heath Walk is now only six weeks away (on Sunday 8th June 2014) and we are all working hard to ensure the day will be a success. Lots of our supporters have already signed up or volunteered to be marshals and we would love you come along and join in as well.
The walk follows a beautiful route across the Heath, and you can chose to walk, jog or run either a 5km or 10km trail. The walk begins at 10.30am (registration opens at 9.15am) and it promises to be a day of fun and laughter. To enter, all you need to do is fill out an entry form, which can be found on our website.
If you don’t want to take part in the walk, but would still like to be involved, please do to volunteer to help on the day. Our marshals and other volunteers play a key role in ensuring the day is a success and any support you can offer is so appreciated.
If you have any questions about either taking part in or volunteering for the walk, please contact me. I can be reached either on firstname.lastname@example.org or 0207 830 2323 and am happy to answer any queries you may have.
Study has identified the first genetic variant which increases the risk of invasive lobular carcinoma
Research published in PLOS Genetics has identified the first genetic variant specifically associated with invasive lobular carcinoma, a breast cancer sub-type.
Invasive lobular carcinoma accounts for 10 to 15 percent of all breast cancer cases. It develops in the lobes of the breast that produce milk and can be difficult to diagnose as the cancer does not always form a definite lump and so may not be seen on a mammogram. Because of this, it is often diagnosed at a later stage when it is more difficult to treat.
This study, co-led by the Institute of Cancer Research, London, King’s College London and Queen Mary University of London was the largest ever to consider this particular breast cancer sub-type. Involving over 100 research institutions, it compared the DNA of over 6,500 women with invasive lobular cancer with more than 35,000 women without the disease.
They found that women with a particular genetic variant, called rs11977670, had a 13 percent higher chance of developing invasive lobular cancer than women without the variant. This discovery, in addition to other markers, could enable genetic screening tools to be developed to assess a woman’s risk of invasive lobular cancer. It also gave new insights into the genetic causes of the disease as well as lobular carcinoma in situ, a precursor to cancer.
In addition to finding a new genetic variant, the scientists evaluated 75 genetic variants previously linked with increased breast cancer risk. They found that most of these were specifically associated with the risk of invasive lobular cancer as well as overall breast cancer risk. The study also showed for the first time that genetic factors that increase the risk of invasive breast cancer can also predispose to lobular carcinoma in situ.
Study co-author Dr Elinor Sawyer said: “A diagnosis of breast cancer can be devastating, particularly if it is not picked up early and the cancer is at a stage when it may be more difficult to treat. This can be the case for lobular breast cancers as they are difficult to see on mammograms. By identifying genetic factors that result in an increased risk of lobular cancer we hope in the future to be able to find better ways of assessing the risk of developing these cancers, so different screening tests can be offered to those at high risk, as well as finding new treatments for lobular cancer.”
Study co-leader Professor Montserrat Garcia-Closas said: “Our study is the first to link a genetic variant specifically with a higher risk of invasive lobular carcinoma, which accounts for around 10 to 15 per cent of all cases. It also finds that more than 50 previously discovered variants specifically increase the risk of lobular tumours, as well as making breast cancer overall more likely.
“Understanding the genetic factors at work in lobular cancers could be particularly important, because they are often missed by mammography because of their unusual growth patterns. In the future, we hope that improving our knowledge of the genes involved in lobular carcinoma could improve our ability to prevent and treat it.”
For more information please visit Breast Cancer Campaign.
Holly Lovering 24 April 2014